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  2. Glutathione: A leading skin antioxidant

Glutathione: A leading skin antioxidant

Skin and antioxidants relationship needs no words of introduction. It is one of the most essential and significant associations that makes skin strong and healthy. Skin comprehends the pool of antioxidants, from enzymatic antioxidants like glutathione peroxidase and catalase to non-enzymatic antioxidants like vitamin C, ubiquinol and glutathione. 

These antioxidants fight against oxidative stress formed due to external and internal free radical formation. This oxidative stress, if not controlled, can lead to skin concerns like premature ageing, inflammation, hyperpigmentation and destructed skin function. 

Therefore, to protect skin from these enemies, an adequate level of antioxidants in the skin is very essential. 

One such antioxidant which plays a significant role in skin rejuvenation is Glutathione. Today, you can find a variety of skincare products enriched with this amazing antioxidant, for instance, glutathione cream, glutathione tablets and it’s serum.


Why is glutathione very essential for skin care and renewal? 

Glutathione, a potent antioxidant, anti-inflammatory, depigmenting and anti-aging agent, helps to lighten hyper-pigmented skin, repairs sun-damaged and photo-aged skin offering clear and bright skin tone.

Let's take a deep look at this amazing skin antioxidant, its importance and effective ways to include in our skin care routine. 

What is glutathione?

Glutathione is a low-molecular weight, small, water-soluble thiol-tripeptide synthesized by three amino acids viz. glutamate, cysteine and glycine. The glutathione is present in two forms; reduced (GSH) and oxidized (GSSG).


The reduced form is known as an active form of glutathione, which aids this molecule to interact with the number of biochemical systems. The active form helps in the process of removing and neutralizing the oxidative free radicals and then turns into the oxidized form and becomes inactive. 

“At rest, healthy cells have GSH/GSSG ration >100, which on exposure to oxidative stress, falls to 1 to 10 cells”

Health benefits of glutathione

Glutathione plays a significant role in pivotal physiological processes leading to impact relevant to various disease pathophysiology, for instance, a decline of oxidative stress, sustenance of redox balance, maintenance of immune system, improvement of metabolic detoxification, and regulation of certain cellular events. 

The chronic diseases, which the glutathione helps to prevent and/or mitigate are:

Ageing and associated concerns, chronic liver disease, Alzheimer's disease, uncontrolled diabetes, stroke, cognitive impairment, hypertension, multiple sclerosis or lupus.

Glutathione for skin 


To keep skin healthy and young, it plays a significant role. This agent not only acts as an astonishing skin-whitening agent but also known to reduce wrinkles, fine lines and improve skin elasticity. All these attributes of glutathione are due to its amazing skin-protecting properties.

Let's explore deeply about these, one on one!

Glutathione antioxidant actions

Being a potent antioxidant, it aids in neutralizing the free radicals formulated due to intense exposure to ultraviolet radiations and environmental pollutants.

The free radicals produced by these environmental aggressors lead to generating reactive oxygen species which leads to damage to cells and tissues of the body. This damage becomes the base of the major skin concerns such as wrinkles, fine lines, dark spots, dull and dry skin. On the whole, your skin starts losing its charm and attractiveness as the structures which hold the moisture become defected.

Your skin needs to detoxify as the levels of toxins become high and it can only be vanished out of the skin when there are adequate levels of antioxidants present in the body. Glutathione helps to balance this disparity and makes skin strong and viable to fight against oxidative stress.

Depigmenting actions of glutathione 


Glutathione is renowned for its depigmenting property. Either in topical or any other form, this molecule has always been in the limelight when it is about getting lighten, brighten and radiant skin. It shows its action on hyperpigmentation via three mechanisms:

  • Inhibition of tyrosinase activity

The very first mechanism via which the glutathione shows its effectiveness against combating the dark spots, patches and uneven skin tone is the inhibition of tyrosinase activity. Tyrosinase is a rate-limiting enzyme in the process of producing melanin (the pigment that imparts colour to the skin) and inhibition of this enzyme significantly affects the levels of melanin.

This process further brightens the skin tone and balances the unevenness. You can read different layers of skin here!

  • Activation of pheomelanin pathway

Another mechanism through which glutathione helps to reduce the effects of hyperpigmentation is the stimulation of the pheomelanin pathway. It tends to convert eumelanin to pheomelanin and regulates the melano cytotoxic agents with or without exposure to the sun.

  • Antioxidant activity

The third mechanism through which the glutathione shows its depigmenting property is via exhibiting antioxidant actions. It scavenges the reactive oxygen species formed in the epidermal cells after intense UV rays exposure. This scavenging and neutralization of oxygen species also contributes to lower the risk of melanogenesis.

Anti-inflammatory benefits of glutathione

Inflammation lies at the root of most skin concerns such as hyperpigmentation and acne. It is a potential anti-inflammatory agent that reduces the levels of pro-inflammatory mediators. This, in turn, helps in reducing acne, melasma and post-inflammatory hyperpigmentation.

Glutathione anti-ageing actions


Glutathione has demonstrated anti-ageing properties. Research studies have shown that glutathione shows a significant impact on reducing wrinkles and increases skin elasticity in all sun-exposed areas.

Now it can be seen from the above-mentioned properties that how essential it is to balance the levels of glutathione in the body. As it not only is a good depigmenting agent that makes your skin brighter and radiant but also a good antioxidant, anti-inflammatory and anti-ageing agent, which makes your skin supple and young. 

Let's explore how we can have this essential skin component externally.

Different ways to include glutathione in skin care routine

Glutathione can be incorporated in the skin care routine through various ways, such as GSH supplements, foods, topical and parenteral formulations:

  • Glutathione supplements


One of the best mediums to boost up the depleted levels of glutathione in the body is having it through the GSH supplements, like, glutathione tablets and capsules. This way you can enrich your body with the adequate quantity of GSH which further aids in restoring the balance between antioxidants and free radicals in the body as the orally administrated glutathione has superior bioavailability.

One of such formulation, which you can rely on is Derma Essentia L Glutathione Tablets. Being enriched with L-glutathione along with vitamin C, these effervescent tablets are best to tackle the cosmetic concerns of the skin, like, hyperpigmentation, age spots, dark spots, melasma and skin ageing. 

These tablets are effervescent, which means, the tablets can readily dissolve, show higher bioavailability and raise the intracellular glutathione to optimum levels. Moreover, the presence of vitamin C in this formulation works as a major beneficial entity which exerts significant influence onto the skin.

You can add these tablets in your day to day routine to get best out of these and provide your skin with a whole rejuvenation.

  • Glutathione Topical Formulations

Other than in supplemental form, you can go for other ways as well to get glutathione to your skin care routine. These are skin care products, like, skin lotions, moisturizers, serums and soaps. These skin care products are the best way to get glutathione via the topical medium. 

Your skin can get this antioxidant directly via these mediums and can repair the concerned problems more effectively. Therefore, along with glutathione supplements, use of skin care products embedded with glutathione would be also beneficial.

  • Foods enriched with glutathione (Glutathione Foods)


Apart from the aforementioned methods to get it, you can also get glutathione in the form of your regular diet. You can take oral glutathione by incorporating some of the antioxidant-enriched foods in the regular diet, you can improve the glutathione status in the body. These foods are polyphenol-rich fruits and vegetables, omega-3 fatty acids, brassica vegetables, lean protein sources, herbs, and green tea.

The recommended dosage of these foods that a person can consume on daily basis is:

Nutrient and Foods 

Recommended Dosage 


1–2 g/day 

Brassica vegetables 

250 g/day 

Fruit and vegetable juices 

300–400 mL/day 

Omega-3 fatty acids 

4000 mg/day 


150 g twice a week 


100–200 ug/day 

Vitamin C 

500–2000 mg/day 

Vitamin E 

100–400 IU/day 


100 mg/kg/day 

Whey Protein 

40 g/day 


600–1200 mg/day 

Alpha lipoic-acid 

200–600 mg/day 

These are the most efficient ways through which you can improve the glutathione levels of your body and skin. Must explore these and include these in your skin care routine to keep your skin rejuvenated and revitalized.

Precautions while having glutathione

Is glutathione safe? This question might be haunting you before using the concerned products in day-to-day life. 

Let's explore are there any precautions or things that needed to take care before using GSH supplements or skin care products.

There are no major complications or recommendations associated with the intake of its supplementation. It is safe to take this antioxidant agent in day to day to life to make your overall health and skin salubrious.

The only thing to consider is to make sure you are not sensitive to this component. Also, consult the doctor before taking this if you are pregnant or a lactating mother. You can consult a dermatologist or physician before including these supplements in your daily routine.

An overview of glutathione in skin care

People might know glutathione only as a depigmenting agent which aids in brightening the skin. However, it is associated with overall skin rejuvenation and restoration. For skin care, it plays a very crucial role and its incorporation in the skin care routine can seriously lead to the marked positive changes in the overall person's looks and charm.

Use glutathione tablets and skincare products and give your skin the punch of antioxidants.


Let's take a look on most frequently asked question associated with glutathione:

Which is the best glutathione supplement?

Health essentia glutathione supplements along with the richness of vitamin C is the best supplement to grab it on a daily basis.

How does glutathione work?

It revives the damaged skin by exhibiting its potent antioxidant and anti-ageing properties. The antioxidant properties aids in balancing the formation of free radicals and anti-ageing properties helps to tackle the photoaging problems like wrinkles, fine lines and dark spots.

How to take glutathione for best results?

It is renowned as a 'master antioxidant'. You can take glutathione effectively in the form of glutathione tablets and glutathione incorporated skin care products. 

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